The role of rhynchophylline in alleviating early brain injury following subarachnoid hemorrhage in rats
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- 作者：Yan Zhanga ; Juan Suna ; Shijie Zhub ; Ting Xua ; Jianfei Lua ; Hongbin Hanc ; d ; Changman Zhoua ; Junhao Yana ; d ; yjh@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARE ; antioxidant response element ; BBB ; blood&ndash ; brain barrier ; CBF ; cerebral blood flow ; EBI ; early brain injury ; GSTs ; glutathione S-transferases ; HO-1 ; heme oxygenase-1 ; keap1 ; Kelch-like ECH-associated protein-1 ; MDA ; malondialdehyde ; MPO ; myeloperoxidase ; MRI ; magnetic resonance imaging ; NQO-1 ; NAD(P)H quinone oxidoreductase ; Nrf2 ; nuclear factor erythroid 2-related factor 2 ; N.S ; normal saline ; Rhy ; Rhynchophylline ; ROI ; region of interesting ; ROS ; reactive oxygen species ; SAH ; subarach
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：1631
- 期：Complete
- 页码：92-100
- 全文大小：1655 K
文摘
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Rhynchophylline attenuates early brain injury after subarachnoid hemorrhage(SAH).
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Rhynchophylline may play its protective role through Nrf2/ARE pathway.
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Nrf2/ARE pathway suppresses inflammation and apoptosis in hippocampus after SAH.