Development of a novel starch with a three-dimensional ordered macroporous structure for improving the dissolution rate of felodipine
详细信息 查看全文
- 作者：Yanna Hao ; Chao Wu ; wuchao27@126.com" class="auth_mail" title="E-mail the corresponding author ; Zongzhe Zhao ; Ying Zhao ; Jie Xu ; Yang Qiu ; Jie Jiang ; Tong Yu ; Chunyu Ma ; Buyun Zhou
- 关键词：Starch ; Three-dimensional ordered macroporous ; Felodipine ; Insoluble drug ; The dissolution rate ; Relative bioavailability
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：58
- 期：Complete
- 页码：1131-1137
- 全文大小：1049 K
文摘
- •
We successfully prepared a starch with a novel three-dimensional ordered macroporous structure (3DOMTS).
- •
3DOMTS can suppress the crystallinity of the drug to maintain it at amorphous state.
- •
In vivo and in vitro experiments proved that 3DOMTS can improve the solubility and bioavailability of felodipine.