Exosomes derived from dendritic cells improve cardiac function via activation of CD4+ T lymphocytes after myocardial infarction
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- 作者：Haibo Liua ; b ; 1 ; haiboliu13@fudan.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Wei Gaoa ; 1 ; govee@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Jie Yuana ; 1 ; yuanjieww@126.com" class="auth_mail" title="E-mail the corresponding author ; Chaoneng Wua ; wuchao1107@126.com" class="auth_mail" title="E-mail the corresponding author ; Kang Yaoa ; yao.kang@zs-hospital.sh.cn" class="auth_mail" title="E-mail the corresponding author ; Li Zhanga ; eileen910128@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Leilei Maa ; mllsdjn@126.com" class="auth_mail" title="E-mail the corresponding author ; Jianbing Zhua ; zhujianbing543@163.com" class="auth_mail" title="E-mail the corresponding author ; Yunzeng Zoua ; zou.yunzeng@zs-hospital.sh.cn" class="auth_mail" title="E-mail the corresponding author ; Junbo Gea ; jbge@zs-hospital.sh.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：DC ; dendritic cell ; BMDC ; bone marrow-derived DC ; MI ; myocardial infarction ; DEXs ; exosomes derived from DCs ; LV ; left ventricular ; APC ; antigen-presenting cell ; CBA ; cytometric bead array
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：123-133
- 全文大小：1742 K
文摘
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MI-DEXs were recruited at a greater number and more rapidly into the mice spleen.
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DEXs interact with CD4+ T cells directly.
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MI-DEXs activate CD4+ T cells by upregulating the Th1 pathway.
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Chemokines secreted by CD4+ T cells recruit DEXs.
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The injection of MI-DEXs improved the cardiac function of mice post-MI.