Chlorpromazine inhibits mitochondrial apoptotic pathway via increasing expression of tissue factor
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- 作者：Jing Wua ; 1 ; wujing.jing@ems.hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Aimei Lia ; 1 ; liaimeiandamy@126.com" class="auth_mail" title="E-mail the corresponding author ; Yujun Lia ; Li_Yujun@126.com" class="auth_mail" title="E-mail the corresponding author ; Xiaoguang Lia ; liqian0041@139.com" class="auth_mail" title="E-mail the corresponding author ; Qingmeng Zhanga ; qmzhang@126.com" class="auth_mail" title="E-mail the corresponding author ; Wuqi Songa ; songwuqi@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Yao Wanga ; 77684507@qq.com" class="auth_mail" title="E-mail the corresponding author ; James O. Ogutua ; b ; ogutujim@yahoo.co.uk" class="auth_mail" title="E-mail the corresponding author ; Jindong Wanga ; wangjd1110@163.com" class="auth_mail" title="E-mail the corresponding author ; Jianbo Lic ; lijianbo136@163.com" class="auth_mail" title="E-mail the corresponding author ; Renkuan Tangc ; tangcqum@163.com" class="auth_mail" title="E-mail the corresponding author ; Fengmin Zhanga ; fengminzhang@ems.hrbmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chlorpromazine ; Bcl-2 ; Tissue factor ; Neuronal apoptosis ; Mitochondrial apoptotic pathway
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：70
- 期：Complete
- 页码：82-91
- 全文大小：3199 K
文摘
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Less apoptotic cells in CPZ-treated schizophrenic brain than in control.
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Upregulation of TF and Bcl-2 in CPZ-treated schizophrenics.
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CPZ treatment increases the levels of Bcl-2 and TF in rat brain.
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Over-expression of TF increases Bcl-2 levels in C6 cells.
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CPZ inhibits mitochondrial apoptotic pathway by increasing levels of TF.