The circadian clock gene Bmal1 acts as a potential anti-oncogene in pancreatic cancer by activating the p53 tumor suppressor pathway
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- 作者：Weiliang Jianga ; 1 ; Senlin Zhaob ; 1 ; Xiaohua Jiangc ; 1 ; Erquan Zhangd ; Guoyong Hua ; Bin Hua ; Ping Zhenge ; Junhua Xiaoe ; Zhanjun Lua ; Yingying Lua ; Jianbo Nia ; Congying Chena ; Xingpeng Wanga ; Lijuan Yanga ; Lijuanyang77@163.com" class="auth_mail" title="E-mail the corresponding author ; Rong Wana ; doctorwanrong1970@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Circadian clock ; Bmal1 ; Pancreatic cancer ; P53 ; Cell cycle arrest ; Apoptosis
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 February 2016
- 年：2016
- 卷：371
- 期：2
- 页码：314-325
- 全文大小：6059 K
文摘
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The expression level of Bmal1 is downregulated in pancreatic cancer (PC) tissues.
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Bmal1 significantly inhibits the proliferation and invasion of PC cells, both in vitro and in vivo.
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Bmal1 could directly bind to the p53 gene promoter.
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Bmal1 is able to induce apoptosis and G2/M cell cycle arrest in PC cells in a p53-dependent manner.