Design, synthesis and cytotoxic activities of scopoletin-isoxazole and scopoletin-pyrazole hybrids

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• 作者：Wei Shi ; Jinglin Hu ; Na Bao ; Dongang Li ; Li Chen ; ^{chenli627@cpu.edu.cn} ; Jianbo Sun ; ^{sjbcpu@gmail.com}
• 关键词：Scopoletin ; Pyrazole ; Isoxazole ; Cytotoxic activity
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：27
• 期：2
• 页码：147-151
• 全文大小：790 K
• 卷排序：27

文摘

12 novel scopoletin-isoxazole and scopoletin-pyrazole hybrids have been designed and synthesized. Their anti-tumor activities against HCT-116, Huh7 and SW 620 cells in vitro were evaluated. Compound 9d displayed significant anti-proliferative activity on tumor cells and weak cytotoxicity on normal cells.