Tet3 Reads 5-Carboxylcytosine through Its CXXC Domain and Is a Potential Guardian against Neurodegeneration
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- 作者：Seung-Gi Jin1 ; 2 ; Zhi-Min Zhang3 ; Thomas L. Dunwell2 ; Matthew R. Harter3 ; Xiwei Wu4 ; Jennifer Johnson1 ; Zheng Li5 ; Jiancheng Liu6 ; Piroska E. Szabó ; 1 ; 4 ; Qiang Lu6 ; Guo-liang Xu5 ; Jikui Song3 ; jikui.song@ucr.edu" class="auth_mail" title="E-mail the corresponding author ; Gerd P. Pfeifer1 ; 2 ; gerd.pfeifer@vai.org" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 January 2016
- 年：2016
- 卷：14
- 期：3
- 页码：493-505
- 全文大小：3750 K
文摘
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The three isoforms of mammalian Tet3 include Tet3FL, Tet3s, and Tet3o
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The CXXC domain of Tet3 is a specific reader of 5-carboxylcytosine at CcaCG sequences
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The crystal structure of the CXXC domain-5caC complex was solved
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Tet3FL in neurons targets genes of the lysosome and base excision repair pathways