Small-Molecule-Based Lineage Reprogramming Creates Functional Astrocytes
详细信息 查看全文
- 作者：E Tian1 ; Guoqiang Sun1 ; Guihua Sun2 ; Jianfei Chao1 ; Peng Ye1 ; Charles Warden3 ; Arthur D. Riggs2 ; Yanhong Shi1 ; yshi@coh.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：direct conversion ; chemical reprogramming ; induced astrocytes ; small molecules ; Alexander disease
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：16
- 期：3
- 页码：781-792
- 全文大小：4472 K
文摘
- •
Fibroblasts can be directly converted into astrocytes with a chemical cocktail
- •
Induced astrocytes resemble primary astrocytes in gene expression profile
- •
Induced astrocytes exhibit similar functional properties as primary astrocytes
- •
Induced astrocytes can be used for disease modeling and drug discovery