Inhibition of listeriolysin O oligomerization by lutein prevents Listeria monocytogenes infection

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• 作者：Bowen Liu¹ ; Zihao Teng¹ ; Jianfeng Wang ; Gejin Lu ; Xuming Deng ; ^{dengxm@jlu.edu.cn} ; Li Li ; ^{lilitonghappy@163.com}
• 关键词：Lutein ; Listeria monocytogenes ; Listeriolysin O ; Oligomerization ; anti-virulence
• 刊名：Fitoterapia
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：116
• 期：Complete
• 页码：45-50
• 全文大小：903 K
• 卷排序：116

文摘

The foodborne pathogenic bacterial species Listeria monocytogenes (L. monocytogenes) has caused incalculable damages to public health, and its successful infection requires various virulence factors, including Listeriolysin O (LLO). By forming pores in phagosomal membranes and even in some organelles, LLO plays an indispensable role in the ability of L. monocytogenes to escape from host immune attacks. Because of its critical role, LLO offers an appropriate therapeutic target against L. monocytogenes infection. Here, lutein, a natural small molecule existing widely in fruits and vegetables, is demonstrated as an effective inhibitor of LLO that works by blocking its oligomerization during invasion without showing significant bacteriostatic activity. Further assays applying lutein in cell culture models of invasion and in animal models showed that lutein could effectively inhibit L. monocytogenes infection. Overall, our results indicate that lutein may represent a promising and novel therapeutic agent against L. monocytogenes infection.