Laquinimod ameliorates spontaneous colitis in interleukin-10-gene-deficient mice with improved barrier function
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- 作者：Jing Sun1 ; Xiao Shen1 ; Jianning Dong ; Jie Zhao ; Lugen Zuo ; Honggang Wang ; Yi Li ; Weiming Zhu ; dr_juwiming@126.com" class="auth_mail" title="E-mail the corresponding author ; Jianfeng Gong ; Jieshou Li
- 关键词：Crohn's disease ; IL-10 gene-deficient mice ; Laquinimod ; Intestinal barrier function ; NF-κB pathway
- 刊名：International Immunopharmacology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：29
- 期：2
- 页码：423-432
- 全文大小：2529 K
文摘
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Laquinimod treatment ameliorated spontaneous colitis in Il10−/− mice.
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Laquinimod treatment can prevent intestinal barrier dysfunction of Il10−/− mice.
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Laquinimod maintains the balance of T-cell-associated inflammatory cytokines.
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The therapeutic effect of laquinimod may also be associated with the NF-κB signaling pathway.