A new semisynthetic 1-O-acetyl-6-O-lauroylbritannilactone induces apoptosis of human laryngocarcinoma cells through p53-dependent pathway
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- 作者：Yang-Yang Hana ; Jiang-Jiang Tangb ; tangjiang11@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Rong-Fang Gaoa ; Xin Guob ; Ming Leia ; c ; leiming70@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Jin-Ming Gaob
- 关键词：Apoptosis ; Britannilactone ; Cell cycle arrest ; p53 ; Laryngocarcinoma
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：35
- 期：Complete
- 页码：112-120
- 全文大小：1352 K
文摘
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A new semisynthetic analogue ABL-L was prepared and demonstrated to show stronger suppression against HEp-2 cells.
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ABL-L-induced inhibition of cell proliferation was associated with an increase in G1-phase arrest of HEp-2 cells.
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ABL-L inhibits the malignant behaviors of HEp-2 cells via a p53-dependent, caspase-mediated pathway.