CUEDC2 interacts with heat shock protein 70 and negatively regulates its chaperone activity
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- 作者：Lin Gonga ; b ; c ; 1 ; Chen Hui Wangb ; 1 ; Yi Jiao Huangb ; Feng Liub ; Teng Lib ; Jiang Daib ; Ai ling Lib ; Tao Zhoub ; Qing Xiab ; qxia@ncba.ac.cn" class="auth_mail ; Liang Chenb ; lchen@ncba.ac.cn" class="auth_mail
- 关键词：CUEDC2 ; HSP70 ; Protein&ndash ; protein interaction ; Chaperone activity
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：25 April 2014
- 年：2014
- 卷：447
- 期：1
- 页码：64-69
- 全文大小：1106 K
文摘
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Mass spectrometry analysis identified HSP70 as a novel CUEDC2 interaction protein.
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The interaction between CUEDC2 and HSP70 is further confirmed.
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CUEDC2 inhibits the chaperone activity of HSP70.
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CUEDC2 might play important roles in regulating HSP70 mediated stress responses.