Adiponectin potentiates the acute effects of leptin in arcuate Pomc neurons
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- 作者：Jia Sun1 ; 8 ; 9 ; Yong Gao2 ; 8 ; 9 ; Ting Yao3 ; 8 ; 9 ; Yiru Huang4 ; 8 ; Zhenyan He4 ; 8 ; Xingxing Kong5 ; Kai-jiang Yu6 ; Rui-tao Wang6 ; Hongbo Guo4 ; Jianqun Yan3 ; Yongsheng Chang2 ; Hong Chen1 ; Philipp E. Scherer7 ; Tiemin Liu6 ; 8 ; ; Kevin W. Williams8 ; Kevin.Williams@UTSouthwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Melanocortin ; Obesity ; Diabetes ; Energy balance ; Patch-clamp ; Electrophysiology
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：5
- 期：10
- 页码：882-891
- 全文大小：1753 K
文摘
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Adiponectin activates arcuate Pomc neurons.
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Adiponectin-induced activation of Pomc neurons requires PI3K (independent of AMPK).
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Adiponectin inhibits adjacent NPY/AgRP neurons (disinhibiting arcuate Pomc neurons).
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Leptin potentiates the effects of adiponectin arcuate Pomc neurons.