β-glucans from Coriolus versicolor protect mice against S. typhimurium challenge by activation of macrophages
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- 作者：Shao-Hua Shi1 ; Wen-Tao Yang1 ; Ke-Yan Huang ; Yan-Long Jiang ; Gui-Lian Yang ; yangguilian@jlau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Chun-Feng Wang ; wangchunfeng@jlau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yu Li ; yuli966@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Coriolus versicolor ; β-glucans ; Macrophages ; NO ; Salmonella typhimurium ; Antibacterial activities
- 刊名：International Journal of Biological Macromolecules
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：352-361
- 全文大小：1487 K
文摘
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There are no detectable cytotoxic effects of β-glucans.
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β-glucans induce strong proliferaion and expresion of CD40, CD80, and CD86 marker of macrophages.
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β-glucans-treated macrophage but not itself can phagocytize and kill S. typhimurium.
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β-glucans induce the production of NO and iNOS from pretreated macrophages.
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β-glucans-treated macrophages are effective at protecting mice against the challenge of S. typhimurium.