Synthesis and characterization of mesoporous magnetic nanocomposites wrapped with chitosan gatekeepers for pH-sensitive controlled release of doxorubicin
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- 作者：Juan Wu ; Wei Jiang ; Yewen Shen ; Wei Jiang ; superfine_jw@126.com" class="auth_mail" title="E-mail the corresponding author ; Renbing Tian
- 关键词：Fe3O4 ; Mesoporous silica ; Chitosan ; Doxorubicin ; pH-sensitive ; Targeted cancer therapy
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：132-140
- 全文大小：2225 K
文摘
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The Fe3O4@mSiO2 with suitable size and good magnetic responsibility were successfully synthesized
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The DOX loaded into carriers at a high drug loading efficiency of 93.6% by electrostatic interaction
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The CS acted as "gatekeeper" was employed to endow the delivery system pH-sensitivity and inhibit premature drug release
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The DOX can be controlled released at pH < 6.0 due to the dissolution of CS
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The CS/Fe3O4@mSiO2-DOX exhibited high anti-tumor activity, while the Fe3O4@mSiO2 was practically non-toxic