SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons

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• 作者：Qingjian Han¹ ; ⁴ ; Yong Ho Kim¹ ; ⁴ ; Xiaoming Wang² ; ⁴ ; Di Liu¹ ; Zhi-Jun Zhang¹ ; Alexandra L. Bey³ ; Mark Lay¹ ; Wonseok Chang¹ ; Temugin Berta¹ ; Yan Zhang¹ ; Yong-Hui Jiang² ; ³ ; ^{yong-hui.jiang@dm.duke.edu} ; Ru-Rong Ji¹ ; ³ ; ⁵ ; ^{ru-rong.ji@duke.edu}
• 关键词：autism spectrum disorders ; ASD ; capsaicin ; dorsal root ganglion ; DRG ; heat hyperalgesia ; human sensory neurons ; mice ; primary sensory neurons ; SHANK3 ; spinal cord dorsal horn ; TRPV1
• 刊名：Neuron
• 出版年：2016
• 出版时间：21 December 2016
• 年：2016
• 卷：92
• 期：6
• 页码：1279-1293
• 全文大小：5534 K
• 卷排序：92

文摘

SHANK3 is expressed in primary sensory neurons and spinal cord central terminals Shank3 haploinsufficiency in sensory neurons leads to impaired heat hyperalgesia SHANK3 in mouse and human DRG neurons regulates TRPV1 function SHANK3 interacts with TRPV1 and modulates presynaptic pain transmission