SNARE-mediated membrane fusion in autophagy

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• 作者：Yongyao Wang^a ; ^b ; ¹ ; Linsen Li^c ; ^d ; ¹ ; Chen Hou^a ; ¹ ; Ying Lai^e ; Jiangang Long^a ; ^{jglong@xjtu.edu.cn} ; Jiankang Liu^a ; Qing Zhong^c ; ^{qing.zhong@utsouthwestern.edu} ; Jiajie Diao^b ; ^{jiajie.diao@uc.edu}
• 关键词：Autophagy ; Membrane fusion ; SNARE
• 刊名：Seminars in Cell & Developmental Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：60
• 期：Complete
• 页码：97-104
• 全文大小：1228 K
• 卷排序：60

文摘

Autophagy, a conserved self-eating process for the bulk degradation of cytoplasmic materials, involves double-membrane autophagosomes formed when an isolation membrane emerges and their direct fusion with lysosomes for degradation. For the early biogenesis of autophagosomes and their later degradation in lysosomes, membrane fusion is necessary, although different sets of genes and autophagy-related proteins involved in distinct fusion steps have been reported. To clarify the molecular mechanism of membrane fusion in autophagy, to not only expand current knowledge of autophagy, but also benefit human health, this review discusses key findings that elucidate the unique membrane dynamics of autophagy.