Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation

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• 作者：Sean D. Kodani^a ; Haley B. Overby^b ; Christophe Morisseau^a ; Jiangang Chen^b ; ^c ; Ling Zhao^b ; Bruce D. Hammock^a ; ^{bdhammock@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：AADAC ; arylacetamide deacetylase ; AEA ; arachidonoyl ethanolamide ; BnP ; benzylparaben ; BuP ; butylparaben ; CB1R ; cannabinoid receptor 1 ; CB2R ; cannabinoid receptor 2 ; CMNA ; cyano(6-methoxynaphthalen-2-yl)methyl acetate ; EC ; endocannabinoid ; FAAH ; fatty acid amide hydrolase ; GR ; glucocorticoid receptor ; hCE1 ; carboxylesterase 1 ; hCE2 ; carboxylesterase 2 ; OMP ; N-(6-methoxypyridin-3-yl) octanamide ; PF-622 ; N-phenyl-4-(quinolin-2-ylmethyl)piperazine-1-carboxamide ; PPARγ ; peroxisome proliferator-activa
• 刊名：Toxicology Letters
• 出版年：2016
• 出版时间：16 November 2016
• 年：2016
• 卷：262
• 期：Complete
• 页码：92-99
• 全文大小：2114 K

文摘

<dl class="listitem" id="list_lis0005"><dt class="label">•dt><dd>

d="par0005">Parabens inhibit the endocannabinoid enzyme fatty acid amide hydrolase (FAAH).

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d="par0010">Paraben inhibition has time-independent, mixed-type kinetics.

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d="par0015">Benzylparaben, the most potent paraben, inhibits FAAH with sub-micromolar potency.

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d="par0020">Endocannabinoids may mediate paraben-enhanced adipogenesis but not through CB₁ activation.

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