Alkaloids from Toddalia asiatica and their cytotoxic, antimicrobial and antifungal activities

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• 作者：Jiang Hu ; Xiaodong Shi ; Jiangang Chen ; Xia Mao ; Lei Zhu ; Long Yu ; Junyou Shi
• 关键词：Toddalia asiatica ; Rutaceae ; Alkaloids ; Cytotoxic ; Antimicrobial ; Antifungal
• 刊名：Food Chemistry
• 出版年：1 April, 2014
• 年：2014
• 卷：148
• 期：Complete
• 页码：437-444
• 全文大小：442 K

文摘

Phytochemical investigation of the ethanol extract from the roots of Toddalia asiatica resulted in the isolation of eight new alkaloids, 8-methoxynorchelerythrine (1), 11-demethylrhoifoline B (2), 8-methoxynitidine (3), 8-acetylnorchelerythrine (4), 8,9,10,12-tetramethoxynorchelerythrine (5), isointegriamide (6), 1-demethyl dicentrinone (7), and 11-hydroxy-10-methoxy-(2,3)-methylenedioxytetrahydroprotoberberine (8), together with 10 known alkaloids. Their structures were determined on the basis of spectroscopic analyses, including 1D-NMR, 2D-NMR, and HR-ESI-MS. The isolated components were evaluated in vitro for cytotoxic activities against eight tumor cell lines, antimicrobial activities against two Gram-positive bacteria and five Gram-negative bacteria, and antifungal activities against five pathogens. Benzo[c]phenanthridine and secobenzo[c]phenantridine alkaloids exhibited significant cytotoxic, antimicrobial and antifungal properties.