Polymorphisms in the 5-hydroxytryptamine receptor 3B gene are associated with heroin dependence in the Chinese Han population
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- 作者：Fangyuan Yina ; Yuanyuan Jia ; Jing Zhanga ; Hao Guoa ; Xin Huanga ; Jianghua Laia ; b ; Shuguang Weia ; b ; weisg@mail.xjtu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：HTR3B ; 5-hydroxytryptamine receptor 3B ; DA ; dopamine ; SNPs ; single nucleotide polymorphisms ; 5-HT ; 5-hydroxytryptamine/serotonin ; MMT ; methadone maintenance treatment ; DSM-IV ; diagnostic and statistical manual of mental disorders ; 4th revision ; UTR ; untranslated regions ; CHB ; Chinese Han of Beijing ; MAF ; minor allele frequency ; HWE ; Hardy-Weinberg equilibrium ; χ2 ; Pearson chi squared ; OR ; odds ratio ; CI ; confidence interval ; LD ; linkage disequilibrium
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：2 December 2016
- 年：2016
- 卷：635
- 期：Complete
- 页码：123-129
- 全文大小：1034 K
文摘
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We investigated the associations between 7 SNPs of HTR3B and heroin dependence.
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Two new SNPs are significantly associated with heroin dependence.
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HTR3B is a susceptibility gene for heroin dependence in Chinese Han population.