Multiple target of hAmylin on rat primary hippocampal neurons

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• 作者：Nan Zhang^a ; ^b ; Shengchang Yang^a ; ^c ; Chang Wang^d ; Jianghua Zhang^a ; Lifang Huo^a ; Yiru Cheng^a ; Chuan Wang^e ; Zhanfeng Jia^e ; Leiming Ren^a ; ^{ren-leiming@263.net} ; Lin Kang^d ; ^{jiepouky@163.com} ; Wei Zhang^a ; ^{weizhang@hebmu.edu.cn}
• 关键词：hAmylin ; Calcium ; Hippocampal neurons ; TRPV4
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：241-251
• 全文大小：2036 K
• 卷排序：113

文摘

High and low concentration of hAmylin acted on the hippocampal neurons through different mechanisms. Action of low concentration hAmylin depending on Amylin receptor whereas high concentration hAmylin via hAmylin oligomers. TRPV4 is a key molecular target mediating cytotoxic effects of hAmylin oligomers on hippocampal neurons.