Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
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- 作者：Jianjun Gao1 ; 6 ; Lewis Zhichang Shi1 ; 6 ; Hao Zhao4 ; 6 ; Jianfeng Chen1 ; Liangwen Xiong1 ; Qiuming He1 ; Tenghui Chen4 ; Jason Roszik2 ; Chantale Bernatchez2 ; Scott E. Woodman2 ; Pei-Ling Chen3 ; Patrick Hwu2 ; James P. Allison4 ; Andrew Futreal5 ; Jennifer A. Wargo3 ; 5 ; Padmanee Sharma1 ; 4 ; 7 ; padsharma@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Melanoma ; anti-CTLA-4 ; ipilimumab ; IFN-γ signaling ; copy-number alteration ; primary resistance
- 刊名：Cell
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：167
- 期：2
- 页码：397-404.e9
- 全文大小：3122 K
文摘
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Melanoma tumors with loss of IFN-γ signaling lack response to ipilimumab
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Cell lines that are resistant to IFN-γ in vitro have defective IFN-γ pathway
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Mice bearing IFNGR1 knockdown tumors have high mortality despite anti-CTLA-4 therapy