文摘
TET2 is acetylated at K110 by p300 and deacetylated by HDAC1/2 Acetylation increases TET2 activity, protein stability, and partnering with DNMT1 Oxidative stress targets TET2/DNMTs to chromatin, increases DNAm and 5hmC TET2 KO induces DNA hypermethylation in a manner similar to oxidative stress