Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats

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• 作者：Wenyan Sun^a ; ^c ; Xin Wang^b ; Chen Hou^d ; Liang Yang^d ; Hongbao Li^c ; Jing Guo^c ; Chanjuan Huo^c ; Molin Wang^c ; Yuwang Miao^c ; Jiankang Liu^d ; ^{j.liu@mail.xjtu.edu.cn} ; Yuming Kang^c ; ^{ykang@mail.xjtu.edu.cn}
• 关键词：Oleuropein ; Mitochondria ; Nrf2 ; Oxidative stress ; Hypertension
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：556-566
• 全文大小：2804 K
• 卷排序：113

文摘

Oxidative stress in the hypothalamus is associated with hypertension. Oleuropein supplementation attenuated hypertension symptoms in SHR. Oleuropein inhibited PVN oxidative stress in SHR. Oleuropein attenuated PVN mitochondrial impairment in SHR. The effect of oleuropein on the PVN may occur via the activation of the Nrf2 pathway.