An efficient and convenient transformation of α-haloketones to α-hydroxyketones using cesium formate

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• 作者：Fung Fuh Wong ; Po-Wei Chang ; Hui-Chang Lin ; Bang-Jau You ; Jiann-Jyh Huang ; Shao-Kai Lin
• 关键词：α ; -Haloketone ; α ; -Hydroxyketone ; Cesium formate ; Transformation
• 刊名：Journal of Organometallic Chemistry
• 出版年：2009
• 出版时间：1 October 2009
• 年：2009
• 卷：694
• 期：21
• 页码：3452-3455
• 全文大小：214 K

文摘

A new safe and convenient transformation has been developed. In the presence of cesium formate in dry MeOH solution, α-haloketones underwent direct conversion reaction to afford α-hydroxyketone in excellent yields. Furthermore, this methodology can be extended and applied in 2-chloro-N-(1,3-diphenyl-1H-pyrazol-5-yl)acetamide, 2-chloro-N-(2,6-dimethylphen-yl)acetamide, 1-(bromomethylsulfonyl)benzene, and N-(bromomethyl)phthalimide to give the corresponding products in moderate to excellent yields.