- 作者：Tony Tong-Lin Wu ; Jyh-Seng Wang ; Bang-Ping Jiann ; Chia-Cheng Yu ; Jeng-Yu Tsai ; Jen-Tai Lin ; Jong-Khing Huang
- 关键词：angiogenesis factor ; prostatic neoplasm ; vascular endothelial growth factor
- 刊名：Journal of the Chinese Medical Association
- 出版年：2007
- 出版时间：September 2007
- 年：2007
- 卷：70
- 期：9
- 页码：380-384
- 全文大小：296 K
Background
The expression of vascular endothelium growth factor (VEGF) has been correlated to the grading and stage of prostate cancers. However, data regarding Taiwanese prostate cancer patients are lacking. The aim of the present study was to examine VEGF expression in our radical prostatectomy specimens.Methods
Fifty-one radical prostatectomy specimens with prostate cancer (15 stage pT2N0, 25 pT3N0, 11 pT2-4 N1) were stained using goat anti-human VEGF polyclonal antibody (AB-293NA; R&D Systems Inc., Minneapolis, MN, USA). The VEGF expression in malignant and nonmalignant prostate tissues was compared. The correlations of VEGF immunoreactivity with Gleason scores and pathologic stages were examined. Mann–Whitney U test was used for comparison of preoperative prostate-specific antigen levels between patients with and without VEGF expression.
Results
Positive VEGF staining was observed in 80.4 % of malignant epithelia, 39.2 % of peritumoral stroma, 68.6 % of benign hyperplastic glands, and 25.5 % of adjacent stroma. There was no difference in VEGF expression between malignant and nonmalignant areas. Advanced disease had significantly higher frequency of stroma but not epithelium VEGF staining as compared to organ-confined disease (p = 0.002 and p = 0.412, respectively). The Gleason 7 and higher tumors had significantly higher frequency of VEGF staining in stroma but not glandular epithelium (p = 0.041 and p = 0.353, respectively). Tumors with positive epithelium VEGF staining had significantly higher PSA levels (21.3 ± 18.1 vs. 10.8 ± 6.8 ng/mL; p = 0.013).
Conclusion
There was no difference in VEGF immunoreactivity between malignant and benign prostatic epithelium in Taiwanese. High Gleason grade tumors and advanced disease had significantly higher frequency of VEGF expression in stroma but not glandular epithelium. Tumors with positive epithelium VEGF staining had significantly higher PSA levels.