Protein phosphatase 2A regulatory subunit B56β modulates erythroid differentiation
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- 作者：Jianping Wud ; 1 ; Jun Wange ; 1 ; Xiansheng Zengf ; 1 ; Yueqiu Chena ; 1 ; Jun Xiaa ; Shizhen Wanga ; Zan Huangc ; huangzan@njau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Weiqian Chena ; chenweiqian@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhenya Shenb ; uuzyshen@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Erythropoiesis ; Erythroid differentiation ; Protein phosphatase 2A ; Regulatory subunits ; B56β ; PPP2R5B
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：23 September 2016
- 年：2016
- 卷：478
- 期：3
- 页码：1179-1184
- 全文大小：1404 K
文摘
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Hemin treatment induces erythroid differentiation of K562 cells.
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Okadaic acid treatment attenuates erythroid differentiation and survival.
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B56β expression is induced by EPO in fetal liver cells or by hemin in K562 cells.
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Knockdown of B56β impairs hemin-induced erythroid differentiation of K562 cells.