A dual-targeting drug co-delivery system for tumor chemo- and gene combined therapy
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- 作者：Fangrong Zhang ; Min Li ; Yujie Su ; Jianping Zhou ; Wei Wang ; wangcpu209@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：DCA ; dichloroacetate ; DCA/p53 ; dichloroacetate/p53 gene ; DSPE-PEG-AA ; 1 ; 2-distearoryl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol-2000)] ammonium salt-anisamide ; PEI ; polyethyleneimine ; DCA-PEI ; dichloroacetate-polyethyleneimine ; rHDL ; reconstituted high-density lipoprotein ; CLSM ; confocal laser scanning microscopy ; SR-BI ; scavenger receptor class B type I ; PDK ; pyruvate dehydrogenase kinase ; ROS ; reactive oxygen species ; PEG ; polyethylene glycol ; FBS ; fetal bovine serum ; EPR
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：208-218
- 全文大小：2179 K
文摘
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DSPE-PEG-AA/rHDL/DCA-PEI/p53 was successful prepared with desirable and homogenous particle size, neutral surface charge, low cytotoxicity in normal cells and dual-targeting ability via the recognition of SR-BI and sigma receptor.
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The anticancer activity was due to the synergistic effects of DCA and p53.