A Correlative Relationship Between Chronic Pain and Insulin Resistance in Zucker Fatty Rats: Role of Downregulation of Insulin Receptors
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- 作者：Xu Zhai&lowast ; ; &dagger ; ; Chunli Sun&lowast ; ; Peijing Rong&dagger ; ; Shaoyuan Li&dagger ; ; Michael F. McCabe&Dagger ; ; Xing Wang&lowast ; ; Jianren Mao&Dagger ; ; Shuxing Wang§ ; ; ¶ ; ; shuxingw@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chronic hypersensitivity ; insulin resistance ; type 2 diabetes ; constriction injury of a unilateral sciatic nerve ; hemoglobin Alc ; insulin receptor ; Zucker Diabetic Fatty rats
- 刊名：The Journal of Pain
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：17
- 期：4
- 页码：404-413
- 全文大小：2104 K
文摘
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Nerve injury downregulated expression of insulin receptors in the innervated skeletal muscle.
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Nerve injury might reduce the glucose metabolism function in the innervated skeletal muscle.
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Nerve injury induced neuropathy accelerated the progression of type 2 diabetes.