Skin 尾-Endorphin Mediates Addiction to UV Light
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- 作者：Gillian L. Fell1 ; 5 ; 6 ; Kathleen C. Robinson1 ; 5 ; Jianren Mao2 ; Clifford J. Woolf3 ; 4 ; David E. Fisher1 ; dfisher3@partners.org" class="auth_mail
- 刊名：Cell
- 出版年：19 June 2014
- 年：2014
- 卷：157
- 期：7
- 页码：1527-1534
- 全文大小：1149 K
文摘
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UV exposure leads to elevated blood levels of 尾-endorphin in mice
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UV causes systemic analgesia that is reversible with opioid receptor blockade
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Chronic UV causes dependency and “addiction”-like behavior
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Addiction-like behaviors require keratinocyte signaling and 尾-endorphin expression