MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition
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- 作者：Huacheng Luo1 ; Anitha K. Shenoy1 ; Xuehui Li2 ; Yue Jin1 ; Lihua Jin5 ; Qingsong Cai1 ; Ming Tang1 ; Yang Liu1 ; Hao Chen1 ; David Reisman3 ; Lizi Wu4 ; Edward Seto6 ; Yi Qiu2 ; Yali Dou7 ; Robert A. Casero Jr.5 ; Jianrong Lu1 ; jrlu@ufl.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：21 June 2016
- 年：2016
- 卷：15
- 期：12
- 页码：2665-2678
- 全文大小：4986 K
文摘
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LSD1 is acetylated in epithelial but not mesenchymal cells
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MOF directly acetylates LSD1 and is required for LSD1 acetylation in epithelial cells
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Ectopic MOF expression reduces LSD1 at epithelial gene promoters and blocks EMT
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MOF inhibits tumor invasion and predicts positive clinical outcomes in human cancer