HIF-1α activates hypoxia-induced PFKFB4 expression in human bladder cancer cells
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- 作者：Hao Zhanga ; 1 ; Chengyin Lub ; 1 ; Meng Fanga ; 1 ; Wangjun Yana ; Mo Chena ; Yingzheng Jia ; Shaohui Hea ; Tielong Liua ; czyyltl@163.com" class="auth_mail" title="E-mail the corresponding author ; Tianrui Chena ; daman123456789@163.com" class="auth_mail" title="E-mail the corresponding author ; Jianru Xiaoa ; jianruxiao83@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bladder cancer ; PFKFB4 ; HIF-1α ; HREs ; Hypoxia
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 July 2016
- 年：2016
- 卷：476
- 期：3
- 页码：146-152
- 全文大小：1439 K
文摘
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Hypoxia upregulates the expression levels of PFKFB4 in human bladder cancer cell lines.
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HIF-1α transactivates hypoxia-responsive elements (HRE)-D of the promoter region of PFKFB4 in hypoxia condition.
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HIF-1α expression is associated with PFKFB4 expression in human BC specimens.