Design, synthesis, and anticancer evaluation of long-chain alkoxylated mono-carbonyl analogues of curcumin
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- 作者：Qiaoyou Wenga ; b ; 1 ; Lili Fua ; 1 ; Gaozhi Chena ; Junguo Huib ; Jingjing Songb ; Jianpeng Fenga ; Dengjian Shia ; Yuepiao Caia ; Jiansong Jib ; jjstcty@sina.com" class="auth_mail" title="E-mail the corresponding author ; Guang Lianga ; wzmcliangguang@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anticancer drug ; Gastric cancer ; Drug design ; MACs ; Apoptosis
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2015
- 出版时间：20 October 2015
- 年：2015
- 卷：103
- 期：Complete
- 页码：44-55
- 全文大小：1930 K
文摘
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We synthesized a series of long-chain alkoxylated mono-carbonyl curcumin analogues.
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The curcumin analogues inhibited tumor cell proliferation and induced apoptosis.
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The curcumin analogues increased PARP cleavage and down-regulated Bcl-2.
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Novel curcumin analogue 28 may represent a new treatment for gastric cancer.