Simultaneous determination of sulfur mustard and related oxidation products by isotope-dilution LC-MS/MS method coupled with a chemical conversion
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- 作者：Meiling Qi1 ; Bin Xu1 ; Jianfeng Wu ; Yajiao Zhang ; Cheng Zong ; Jia Chen ; Lei Guo ; Jianwei Xie ; xiejw@bmi.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sulfur mustard ; Mustard sulfoxide ; Mustard sulfone ; Chemical conversion ; HPLC&ndash ; MS/MS ; Whole blood ; Toxicokinetics
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：1028
- 期：Complete
- 页码：42-50
- 全文大小：1647 K
文摘
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A derivatization approach for simutaneously determination of SM, SMO and SMO2 was developed.
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Significant time-dependent responses of SM, SMO and SMO2 were observed after dermal exposed to SM.
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SMO was the major product in whole blood and some of them continued to be oxidized to SMO2in vivo.
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It is the first time reported that the SMO2 was detected and identified in rat blood in vivo.