Clinical, epidemiological and virological characteristics of the first detected human case of avian influenza A(H5N6) virus
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- 作者：Rusheng Zhanga ; b ; Tianmu Chenb ; 1 ; 13698665@qq.com" class="auth_mail" title="E-mail the corresponding author ; Xinhua Oub ; Ruchun Liub ; Yang Yangc ; Wen Yeb ; Jingfang Chenb ; Dong Yaob ; Biancheng Sunb ; Xixing Zhangb ; Jianxiang Zhoud ; Yan Sune ; Faming Chenb ; 1 ; 351985738@qq.com" class="auth_mail" title="E-mail the corresponding author ; Shi-Ping Wanga ; 1 ; spwang@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Avian influenza ; H5N6 ; The first detected human case ; Reassortant ; Sequence
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：236-242
- 全文大小：832 K
文摘
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Phylogenetic analysis demonstrated that the new isolate, A/Changsha/1/2014 (H5N6), is a novel triple reassortant H5N6 virus.
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A/Changsha/1/2014 (H5N6) has not gained genetic mutations necessary for efficient human infection.
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Sequence data of A/Changsha/1/2014 (H5N6) indicate neuraminidase sensitivity and adamantane resistance.
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Detection of asymptomatic carriers should be part of future contact-tracing plans.
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Neuraminidase inhibitors may serve as the frontline intervention for preventing and controlling potential outbreaks.