The ABCB1-C3435T polymorphism likely acts as a risk factor for resistance to antiepileptic drugs
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- 作者：Minzhi Lia ; 1 ; Jinjing Tanb ; 1 ; Xiaoqing Yangc ; 1 ; Li Sud ; 1 ; Juanjuan Xieb ; Baoyun Liangb ; Jianxiong Longd ; Haiyun Jiangb ; Qiugui Weib ; Tingting Shenb ; Qing Chenb ; Yan Yanb ; Guangliang Wub ; Lian Gub ; gulian2012@163.com" class="auth_mail
- 关键词：ABCB1-C3435T ; Polymorphism ; Epilepsy ; Antiepileptic drugs ; Meta-analysis
- 刊名：Epilepsy Research
- 出版年：August 2014
- 年：2014
- 卷：108
- 期：6
- 页码：1052-1067
- 全文大小：2472 K
文摘
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8716 epilepsy patients from 38 independent studies were included.
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Six models were used for comparisons of genotypes in meta-analyses.
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Significant associations of C3435T with resistance to AEDs were showed.
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Subgroup analyses based on different factors were done.
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Cumulative meta-analyses by publication year and sample size were adopted.