Lactobacillus plantarum vaccine vector expressing hemagglutinin provides protection against H9N2 challenge infection
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- 作者：Shao-Hua Shia ; 1 ; Wen-Tao Yanga ; 1 ; Gui-Lian Yanga ; 1 ; Xu-Ke Zhangb ; Yu-Ying Liua ; Li-Jiao Zhanga ; Li-Ping Yea ; Jing-Tao Hua ; Xin Xinga ; Chong Qic ; Yu Lia ; yuli966@126.com" class="auth_mail" title="E-mail the corresponding author ; Chun-Feng Wanga ; wangchunfeng@jlau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hemagglutinin ; Dendritic cell-targeting peptide ; Lactobacillus plantarum ; H9N2 influenza virus ; Mucosal vaccination
- 刊名：Virus Research
- 出版年：2016
- 出版时间：4 January 2016
- 年：2016
- 卷：211
- 期：Complete
- 页码：46-57
- 全文大小：4869 K
文摘
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IFN-γ cytokines, and CD107a+ producing CD3+CD8+ T cells in the spleen and MLN were induced by the NC8-pSIP409-HA-DCpep in mouse models.
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NC8-pSIP409-HA-DCpep provided 100% protection against the mouse-adapted H9N2 virus (H9N2 m-AV) and reduced virus replication in the lungs after challenge with H9N2 m-AV.
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NC8-pSIP409-HA-DCpep induced strong T cell immune response in the PBMC in chickens.
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IgG and sIgA were significantly induced by the NC8-pSIP409-HA-DCpep in chickens.
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Oral vaccination with NC8-pSIP409-HA-DCpep induced protective immunity against H9N2 AIVs in chickens.