Cadmium induced inhibition of autophagy is associated with microtubule disruption and mitochondrial dysfunction in primary rat cerebral cortical neurons
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- 作者：Tao Wang ; Qiwen Wang ; Ruilong Song ; Yajing Zhang ; Jinlong Yang ; Yi Wang ; Yan Yuan ; Jianchun Bian ; Xuezhong Liu ; Jianhong Gu ; Jiaqiao Zhu ; Zongping Liu ; liuzongping@yzu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Autophagy ; Cadmium ; Neuronal toxicity ; Mitochondria ; Microtubules
- 刊名：Neurotoxicology and Teratology
- 出版年：2016
- 出版时间：January-February 2016
- 年：2016
- 卷：53
- 期：Complete
- 页码：11-18
- 全文大小：1832 K
文摘
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Cadmium induced biphasic autophagic responses and inhibition of autophagy associated with depolymerize microtubles.
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Microtuble disruption induced by Cadmium caused mitochondrial dysfunction in neurons.
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Taxol promoted mitochondria-protective autophagy via protecting microtubule from Cadmium neurotoxicity.