Huaier polysaccharides suppresses hepatocarcinoma MHCC97-H cell metastasis via inactivation of EMT and AEG-1 pathway
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- 作者：Jiasheng Zheng ; Cong Li ; Xia Wu ; Mengmeng Liu ; Xicai Sun ; Yingzhuo Yang ; Meijun Hao ; Shoupeng Sheng ; Yu Sun ; Honghai Zhang ; Jiang Long ; Yi Liang ; Caixia Hu
- 关键词：Anti-metastasis ; Astrocyte elevated gene-1 (AEG-1) ; Hepatocellular carcinoma ; MHCC97-H cells ; Huaier polysaccharide
- 刊名：International Journal of Biological Macromolecules
- 出版年：March, 2014
- 年：2014
- 卷：64
- 期：Complete
- 页码：106-110
- 全文大小：1258 K
文摘
We have recently reported that astrocyte elevated gene-1 (AEG-1) might be an epithelial-mesenchymal transition (EMT) associated biomarker in human hepatocellular carcinoma (HCC), and play an important role in the progression of hepatocellular carcinoma. To extend our study, we examined here the anti-invasive and metastatic effects of Huaier polysaccharide (HP) on human HCC cell line MHCC97-H and explored its possible mechanism of action. Treatment with HP dose-dependently inhibited the proliferation, adhesion, migration and invasion of MHCC97-H cells in vitro. This was achieved not only by reducing the expression of AEG-1 and N-cadherin, but also by enhancing E-cadherin expression. Therefore, these data suggested that HP can inhibit the growth and metastatic potential of MHCC97-H cells through modulation of the AEG-1/EMT pathway.