Nuclear PTEN interferes with binding of Ku70 at double-strand breaks through post-translational poly(ADP-ribosyl)ation
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- 作者：Jiawei Guan1 ; Qian Zhao1 ; Weifeng Mao ; maoweifeng@dmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：PTEN ; Double-strand breaks ; Non-homologous end-joining ; Homologous recombination ; Ku70 ; Poly(ADP-ribosyl)ation
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：1863
- 期：12
- 页码：3106-3115
- 全文大小：1552 K
文摘
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Nuclear PTEN promotes homologous recombination but restrains non-homologous end joining repair.
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Nuclear PTEN interferes with binding of Ku70 at DNA breaks.
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Nuclear PTEN regulates stability of PARP1 and the poly(ADP-ribosyl)ation of Ku70.
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Absence of nuclear PTEN rather than phosphatase-negative PTEN sensitizes cell to anti-tumor DNA damage drugs.