Pharmacokinetics and pharmacodynamics of sulfamethoxazole and trimethoprim in swimming crabs (Portunus trituberculatus) and in vitro antibacterial activity against Vibrio: PK/PD of SMZ-TMP in crabs and antibacterial activity against Vibrio
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- 作者：Guihong Fua ; snow03221@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Jiahong Penga ; b ; pjhong2010@163.com" class="auth_mail" title="E-mail the corresponding author ; Yuan Wanga ; wy9501@yeah.net" class="auth_mail" title="E-mail the corresponding author ; Shu Zhaoa ; zhaoshumyfriend@126.com" class="auth_mail" title="E-mail the corresponding author ; Wenhong Fanga ; fwenhong@163.com" class="auth_mail" title="E-mail the corresponding author ; Kun Hub ; khu@shou.ecu.cn" class="auth_mail" title="E-mail the corresponding author ; Jinyu Shenc ; sjinyu@126.com" class="auth_mail" title="E-mail the corresponding author ; Jiayun Yaoc ; yaojiayun@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：PK-PD ; pharmacokinetics-pharmacodynamics ; SMZ ; sulfamethoxazole ; TMP ; trimethoprim ; MICs ; minimum inhibitory concentration ; LOQs ; limits of quantification
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：46
- 期：Complete
- 页码：45-54
- 全文大小：954 K
文摘
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The antibacterial activity against Vibrios showed the in vitro activity during various SMZ-TMP ratios.
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The pharmacokinetics of SMZ-TMP were explored the pharmacokinetic properties of SMZ-TMP combination in tissue of crabs.
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We recommend SMZ-TMP combination in ratio of 1:1 was used to cure the bacterial disease in crabs.