Meta-analysis of the association between asthma and serum levels of high-density lipoprotein cholesterol and low-density lipoprotein cholesterol

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• 作者：Jiayu Peng ; BS ; Ying Huang ; MD ; ^{huangying126163@126.com}
• 刊名：Annals of Allergy, Asthma & Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：118
• 期：1
• 页码：61-65
• 全文大小：770 K
• 卷排序：118

文摘

The reported associations of blood lipid profiles with asthma are ambiguous.ObjectiveTo explore the association between asthma and the serum levels of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C).MethodsA systematic search was performed in the PubMed, MEDLINE, Cochrane Library, and Chinese Biomedical Literature databases. Ten studies were identified. We divided these studies into 2 subgroups according to age: children (<18 years old) and adults (≥18 years old).ResultsIn children, the asthma group had lower HDL-C levels (weighted mean difference, −3.44; 95% confidence interval [CI], −5.83 to −1.04; P = .005) compared with the nonasthma group, whereas the serum levels of LDL-C in these 2 groups were not statistically different. In contrary, in adults, the asthma group had higher LDL-C levels (weighted mean difference, 8.95; 95% confidence interval, 3.55–14.35; P = .001) compared with the nonasthma group, whereas the HDL-C levels were not statistically different.ConclusionThere is a significant association between asthma and the serum levels of HDL-C and LDL-C. Moreover, this association differs in children and adults.