Prevalence and severity of coronary artery calcification based on the epidemiologic pattern: A propensity matched comparison of asymptomatic Korean and Chinese adults

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• 作者：Donghee Han^a ; ^c ; ¹ ; Yang Gao^b ; ¹ ; Brí ; ain ó ; Hartaigh^c ; Heidi Gransar^d ; Ji Hyun Lee^a ; ^c ; Asim Rizvi^c ; Su-Yeon Choi^e ; Eun Ju Chun^f ; Jidong Sung^g ; Hae-Won Han^h ; Sung Hak Parkⁱ ; James K. Min^c ; Bin Lu^b ; ^{blu@vip.sina.com} ; Hyuk-Jae Chang^a ; ^{hjchang@yuhs.ac}
• 关键词：Coronary artery calcium score ; East Asian ; Risk factors ; Coronary artery disease ; Epidemiology
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：230
• 期：Complete
• 页码：353-358
• 全文大小：439 K
• 卷排序：230

文摘

Lifestyle, environmental, and genetic factors substantially influence cardiovascular disease (CVD) risk. We aimed to explore epidemiologic trends in coronary artery calcium scores (CACS), as a marker of CVD, along with possible differences by geographic area and study period in separate East Asian populations.MethodsWe generated 3 matched groups (n = 702) using a propensity scoring approach derived from a Korean (N = 48,901) and Chinese cohort (N = 927) as follows: (1) A recent Chinese group and (2) recent Korean group, both of whom underwent CACS scanning from 2012–2014; and (3) a past Korean group who underwent CACS scanning 8–10 years before the index group (2002–2006). We used logistic regression to generate odds ratios (OR) with 95% confidence intervals (95% CI) to estimate the likelihood of having CACS between the groups, based on CACS stratified by severity: > 0 (any), > 100 (moderate), and > 400 (severe).ResultsThe prevalence of any, moderate, or severe CACS did not differ significantly between the recent Chinese and Korean groups. Notably, the odds of the presence of moderate CACS in the recent Chinese group (OR: 3.05, 95% CI: 1.49–6.71, P-value < 0.001) and the presence of any CACS in the recent Korean group (OR: 1.58, 95% CI: 1.17–2.15, P-value < 0.001) were significantly higher than in the past Korean group.ConclusionsIn this study involving separate East Asian populations, there were no geographic differences in the prevalence of CACS. However, changes in other unmeasured factors over time are likely the culprits for the elevated prevalence of CACS in asymptomatic East Asians.