Inhibition of TRPC3 downregulates airway hyperresponsiveness, remodeling of OVA-sensitized mouse

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• 作者：Lingwei Wang^a ; ¹ ; Jie Li^a ; ^b ; ¹ ; Jian Zhang^c ; ¹ ; Qi He^a ; Xuanwen Weng^a ; Yanmei Huang^a ; Minjie Guan^a ; Chen Qiu^a ; ^{qiuchen@email.jnu.edu.cn}
• 关键词：TRPC3 ; ASMCs ; AHR ; Proliferation ; Migration ; Asthma
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：26 February 2017
• 年：2017
• 卷：484
• 期：1
• 页码：209-217
• 全文大小：4063 K
• 卷排序：484

文摘

Penh, airway remodeling and the gene expression and protein of TRPC3 are increased in OVA-sensitized mice. Inhibition of TRPC3 suppresses the OVA-sensitized mice Penh and airway remodeling. Inhibition of TRPC3 decreases OVA-sensitized mice ASMC proliferation and migration.