Targeted Fe-filled carbon nanotube as a multifunctional contrast agent for thermoacoustic and magnetic resonance imaging of tumor in living mice

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• 作者：Wenzheng Ding ; PhD^a ; Cunguang Lou ; PhD^a ; Jieshan Qiu ; PhD^b ; Zongbin Zhao ; PhD^b ; Quan Zhou ; MD^c ; Minjie Liang ; MD^c ; Zhong Ji ; PhD^a ; Sihua Yang ; PhD^a ; Da Xing ; PhD^a ; ^{xingda@scnu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Fe-filled carbon nanotube ; Contrast agent ; Thermoacoustic molecular imaging ; MRI ; Targeted tumor imaging
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：12
• 期：1
• 页码：235-244
• 全文大小：1721 K

文摘

Microwave-induced thermoacoustic imaging (TAI) can map the microwave absorption distribution of targets, which depends on the electrical and magnetic properties. Although carbon nanotubes (CNTs) with good electrical properties have been used as TAI contrast agents, the negligible magnetic absorption hinders its application for sensitive detection. In order to exploit CNTs with electrical and magnetic absorption properties as agent of TAI, the ferromagnetic material-filled multi-walled CNTs (MMWCNTs) are investigated. In this study, the folic acid conjugated plain multiwalled CNTs (MWCNTs) and MMWCNTs were injected through the tail-vein of mice separately, and TAI and magnetic resonance imaging (MRI) were performed. The results show the MMWCNTs can clearly image the size and edge of the tumor with the TAI contrast enhancement of 67% and T₂ signal intensity decrease of four fifths compared to MWCNTs. This study demonstrated the hybrid particles have the potential to be a high-sensitive contrast agent for accurate tumor detection.

From the Clinical Editor

Novel imaging modalities are emerging. Microwave-induced thermoacoustic imaging (TAI) relies on the absorption distribution of microwave of targets. In this article the authors investigate the use of ferromagnetic material-filled multi-walled CNTs as contrast agents for both TAI and MRI in an in-vivo model for tumors. The positive findings would imply that the application of dual-modality probe could provide more accurate imaging for the clinical setting.