Tumor-Induced Hyperlipidemia Contributes to Tumor Growth
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- 作者：Jianfeng Huang1 ; 2 ; Lena Li2 ; 3 ; Jihong Lian2 ; 3 ; Silvia Schauer1 ; Paul W. Vesely1 ; 5 ; Dagmar Kratky4 ; Gerald Hoefler1 ; gerald.hoefler@medunigraz.at" class="auth_mail" title="E-mail the corresponding author ; Richard Lehner2 ; 3 ; richard.lehner@ualberata.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：12 April 2016
- 年：2016
- 卷：15
- 期：2
- 页码：336-348
- 全文大小：4072 K
文摘
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Lipoprotein cholesterol supports tumor growth
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Tumors increase VLDL/LDL levels
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Ces3/TGH deficiency attenuates tumor-induced hyperlipidemia via inhibition of PCSK9
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Tumor growth was suppressed in Ces3/Tgh−/− mice