MEK1/2 inhibitors induce interleukin-5 expression in mouse macrophages and lymphocytes
详细信息 查看全文
- 作者：Xiaoju Lia ; Xingyue Caoa ; Xiaomeng Zhanga ; Yanhua Kangb ; Wenwen Zhanga ; Miao Yua ; Chuanrui Maa ; Jihong Hanc ; a ; Yajun Duanc ; a ; yajunduan@nankai.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yuanli Chenc ; d ; yuanli2014@nankai.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atherosclerosis ; Interleukin-5 ; Macrophage ; MEK1/2 inhibitor ; oxLDL
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：13 May 2016
- 年：2016
- 卷：473
- 期：4
- 页码：939-946
- 全文大小：1738 K
文摘
- •
MEK1/2 inhibitors activate IL-5 production both in vitro and in vivo.
- •
MEK1/2 inhibitors induce IL-5 expression by activating IL-5 transcription and enhancing IL-5 protein stability.
- •
Induction of IL-5 production may make contribution to the anti-atherogenic properties of MEK1/2 inhibitors.