Solid inclusion complexes of oleanolic acid with amino-appended β-cyclodextrins (ACDs): Preparation, characterization, water solubility and anticancer activity
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- 作者：Yufeng Rena ; 1 ; Ying Liub ; 1 ; Zhikuan Yangb ; Raomei Niua ; 2 ; Kai Gaoa ; Bo Yanga ; Xiali Liaoa ; xlliao@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Jihong Zhangb ; c ; zhangjihong2000@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Oleanolic acid ; Amino-appended β-cyclodextrin ; Inclusion complex ; Binding behavior ; Water solubility ; Anticancer activity
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：69
- 期：Complete
- 页码：68-76
- 全文大小：1879 K
文摘
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Solid inclusion complexes of oleanolic acid (OA) with well-designed amino-appended β-cyclodextrins (ACDs) were prepared.
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Inclusion complexes were intensively characterized by NMR, SEM, XRD, TG, DSC and Zeta potential measurement, etc.
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A 1:2 inclusion mode was suggested based on 1H NMR and ROESY analyses.
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Water solubility of OA was dramatically promoted by complexation with ACDs compared to that of native OA.
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In vitro cytotoxicity of inclusion complexes on human cancer cell lines HepG2, HT29 and HCT116 was significantly enhanced.