Altered behavior and neural activity in conspecific cagemates co-housed with mouse models of brain disorders
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- 作者：Hyunwoo Yanga ; 1 ; Seungmoon Junga ; 1 ; Jinsoo Seoa ; Arshi Khalida ; Jung-Seok Yoob ; Jihyun Parkb ; Soyun Kimb ; Jangsup Moonb ; Soon-Tae Leeb ; Keun-Hwa Jungb ; Kon Chub ; stemcell.snu@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sang Kun Leeb ; sangkun2923@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Daejong Jeonb ; c ; clark.jeon@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Social stress ; Psychosocial environment ; Co-housing ; Mouse ; Behavior ; Prefrontal cortex
- 刊名：Physiology & Behavior
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：163
- 期：Complete
- 页码：167-176
- 全文大小：1050 K
文摘
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We examined the impact of an unstable social environment on behaviors in the mouse.
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Epilepsy or depression mouse models were housed long-term with normal conspecifics.
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Conspecific cagemate mice developed chronic behavioral dysfunctions.
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Conspecific cagemate mice showed abnormal neural activity in mPFC.