Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation
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- 作者：Natalia B. Pikor1 ; Jillian L. Astarita2 ; 3 ; 4 ; Leslie Summers-Deluca1 ; Georgina Galicia1 ; Joy Qu1 ; Lesley A. Ward1 ; Susan Armstrong1 ; Claudia X. Dominguez4 ; Deepali Malhotra2 ; 3 ; Brendan Heiden2 ; 3 ; Robert Kay1 ; Valera Castanov1 ; Hanane Touil5 ; Louis Boon6 ; Paul O&rsquo ; Connor7 ; Amit Bar-Or5 ; Alexandre Prat8 ; Valeria Ramaglia10 ; Samuel Ludwin9 ; Shannon J. Turley2 ; 3 ; 4 ; Jennifer L. Gommerman1 ; jen.gommerman@utoronto.ca" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：43
- 期：6
- 页码：1160-1173
- 全文大小：5465 K
文摘
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A fibroblastic reticular cell (FRC) network forms in the meninges during EAE
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Meningeal FRCs express cytokines and chemokines during EAE
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Inhibition of IL-17 and IL-22 in the CNS short circuits FRC remodeling
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LTβR+ radio-resistant cells promote T cell cytokine production in the CNS